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Stages of Periodontal Disease

Periodontal disease begins when the bacteria in the plaque around your teeth produce toxin (or poison) that irritate the gums, causing infection. These toxins can lead to destruction of the tissue and bone around the teeth. When this happens, the gums separate from the teeth to from a pocket-called a periodontal pocket. As more tissue and bone are destroyed, the pockets get bigger and the teeth may loosen.

Orthodontist Sunrise

Warning Signs

The following signs may give a clue to having gum disease. If you have any of them, call your dentist right away.

  • Bleeding from your gums when you brush
  • Red, swollen, or tender gums
  • Bad bretah or bad taste
  • Loose teeth
  • Gums that have pulled away from your teeth
  • Pus in-between your teeth and gums when you press down on the gums
  • A change in the way your teeth fit together when you bite down
  • Any changes in the fit of partial dentures

It is possible not to have these warming signs and still have gum disease. Also, most people do not feel pain with the disease. This is why regular checkups are important.

Initially

Healthy Gum

Healthy gums are firm and pink.

1st Stage

Gingivitis

This is the earliest state of gum disease. The gums are red, swollen, and bleed easily.

2nd Stage

Mild Periodontitis

The gums begin to separate from the teeth, forming pockets which fill with plaque.

3rd Stage

Moderate Periodontitis

Deeper pockets form as more bone and tissue are lost.

4th Stage

Severe Periodontitis

Teeth may become loose because a large amount of bone and tissue have been lost.

healthygum
gingivitis
mild
moderate
severe

ARESTIN®

OraPharma’s initial product, ARESTIN®, represents a promising therapeutic advance for the adjunct treatment of periodontal disease.

ARESTIN® is the first locally administered time-released antibiotic encapsulated in microspheres that effectively kills the germs that cause periodontal disease or periodontitis, a disease that affects more than 50 million people in the U.S.

ARESTIN® (minocycline HCl 1mg) microspheres is a locally delivered antibiotic used for the treatment of chronic periodontitis. ARESTIN® is indicated as an adjunct to scaling and root planing (SRP) procedures for reduction of pocket depth in patients with adult periodontitis. ARESTIN® may be used as part of a periodontal program which includes good oral hygiene, and scaling and root planing.

ARESTIN® contains minocycline, a tetracycline derivative, and therefore should not be used in children and in pregnant or nursing women. The use of drugs of the tetracycline class during tooth development may cause permanent discoloration of the teeth.

The most common treatment-emergent adverse events were headache (9.0%), infection (7.6%), flu syndrome (5.0%), and pain (4.3%). These occurred at a similar rate to SRP and SRP+placebo.

Periodontitis is an infection of the gums, which if left untreated, can lead to tooth loss and may be linked to other serious diseases such as cardiovascular disease, osteoporosis and diabetes. ARESTIN® uses new microsphere technology to easily and effectively kill the germs that cause periodontal disease.

Periodontal disease occurs when bacteria builds up on your teeth under the gums, causing your gums to become red and swollen. This condition may eventually result in damage to the ligaments and bone that hold your teeth in place, forming pockets around your teeth. As the disease progresses and these pockets become deeper, your teeth can become loose and fall out. Dentists and registered dental hygienists can tell how severe a patient’s periodontitis is by measuring pocket depth and reviewing patient x-rays.

ARESTIN® is the antibiotic and is administered locally, directly into the infected pockets between your teeth. A dentist or dental hygienist can administer ARESTIN® after scaling and root planing, a common procedure used to treat periodontal disease.

When used together with scaling and root planing, ARESTIN® significantly reduces the depth of infected pockets and helps prevent disease progression. A combined therapy ofARESTIN® plus scaling and root planing is more effective at fighting periodontal disease than scaling and root planing alone. ARESTIN® was shown to be particularly even effective in even the more difficult to treat patients such as smokers or people who have cardiovascular disease.

For more information about this exciting product, please visit their web site atwww.Arestin.com

What is ARESTIN®?

Minocycline Microspheres Make it Different
ARESTIN® : Effective and Easy to Administer
Effective in Clinical Trials
ARESTIN® : Clinical Questions and Answers
ARESTIN® is indicated as an adjunct to scaling and root planing (SRP) procedures for reduction of pocket depth in patients with adult periodontitis. ARESTIN® may be used as part of a periodontal program which includes good oral hygiene, and scaling and root planing.

ARESTIN® contains minocycline, a tetracycline derivative, and therefore should not be used in children and in pregnant or nursing women. The use of drugs of the tetracycline class during tooth development may cause permanent discoloration of the teeth.

The most common treatment-emergent adverse events were headache (9.0%), infection (7.6%), flu syndrome (5.0%), and pain (4.3%). These occurred at a similar rate to SRP and SRP+placebo.

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